Animal-free assays for endocrine disruption (AFARA)

Version 1.2
Janine Ezendam, 2026, "Animal-free assays for endocrine disruption (AFARA)", https://doi.org/10.21945/DE9E3740-8261-4883-B7C7-78CE4D3B2F6F, RIVM, V1
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Description
Het AFARA-project streeft ernaar het proces van acceptatie en implementatie van diervrije modellen te versnellen bij de beoordeling van de veiligheid van hormoonverstorende stoffen voor de mens. Hormoonverstorende stoffen worden steeds vaker in verband gebracht met verschillende menselijke ziekten die via het endocriene systeem werken, en omvatten stoffen zoals Bisfenol A, ftalaten en PFAS. Bescherming van de volksgezondheid tegen de mogelijk schadelijke effecten van blootstelling aan hormoonverstorende stoffen vraagt om robuuste en teststrategieën die relevant zijn voor de mens. Het doel van het AFARA-project is om de weg te vergemakkelijken voor regulatoire acceptatie van bestaande modellen voor hormoonverstoren die zowel proefdiervrij zijn als relevant voor de mens. In een divers en interdisciplinair consortium zullen we de uitdagingen en kansen identificeren binnen de bestaande Europese wettelijke en regulatoire kaders voor het gebruik van proefdiervrije modellen bij de identificatie van hormoonverstorende stoffen. Daarnaast zullen we deze lessen toepassen om de verdere ontwikkeling en validatie van proefdiervrije modellen door modelontwikkelaars te ondersteunen, specifiek voor de identificatie van twee klassen van hormoonverstorende stoffen die onvoldoende worden aangepakt in huidige teststrategieën. Het gaat om schildklierontregelende chemicaliën (Thyroid Disrupting Chemicals) en metabolisme-ontregelende chemicaliën (Metabolilic system Disrupting Chemicals). Uiteindelijk zullen de resultaten van het AFARA-project ervoor zorgen dat modelontwikkelaars en andere belanghebbenden op het gebied van hormoonverstoring beter in staat zijn te werken aan de weg naar regulatoire acceptatie van diervrije methoden voor de identificatie van hormoonverstorende stoffen
Theme Health
Keyword hormoonverstoring, proefdiervrij, regulatoire acceptatie, schildklier, validatie
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