Afweer tegen bacteriële infecties

Version 1.1
Rijksinstituut voor Volksgezondheid en Milieu, 2026, "Afweer tegen bacteriële infecties", https://doi.org/10.21945/C0369A77-6883-49CB-AE9A-752509DB5F7E, RIVM, V1
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Description
Dit project richt zich op het onderzoeken van immunologische bescherming tegen bacteriële infecties, met als doel de volksgezondheid beter te beschermen tegen ziekteverwekkers zoals Streptococcus pneumoniae (pneumokokken) en Bordetella pertussis (kinkhoest). Ondanks bestaande vaccinaties veroorzaken deze bacteriën in Nederland nog steeds aanzienlijke ziektelast, vooral bij jonge kinderen en ouderen. Het project heeft als doel inzicht te bieden in de variatie en mechanismen van de immuunrespons na infectie en vaccinatie, zodat effectievere preventiestrategieën kunnen worden ontwikkeld. Het project bestaat uit twee hoofdonderdelen: 1) Pneumokokkenonderzoek: Onderzoek naar B- en T-cel afweerreacties tegen pneumokokken in verschillende leeftijdsgroepen, op basis van gegevens van gezonde donoren en samples uit de Immfact-studie. De dataset bevat naast immunologische analyses (zoals T-cel fenotypering, cytokineproductie, genexpressie via single-cell sequencing en resultaten uit in vitro epitheelmodellen) ook demografische en klinische gegevens, zoals leeftijd, geslacht, vaccinatiestatus en eventuele klachten. 2) Kinkhoestonderzoek: Onderzoek naar immuunresponsen op kinkhoestvaccinatie, waarbij data zijn verzameld in het kader van de BERT- en Immfact-studies. De dataset omvat serologische metingen (IgG-niveaus tegen kinkhoestantigenen), functionele analyses van antilichamen, T-cel analyses en uitgebreide immuuncelprofielen in bloed, aangevuld met demografische en klinische gegevens zoals leeftijd, geslacht, vaccinaties, doorgemaakte infecties en gerapporteerde klachten.
Theme Science and technology
Keyword T-cellen, bacteriën, infectieziekten, kinkhoest, pneumokokken, specifieke afweer systeem, vaccinatie
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