Integrated in vitro toxicokinetics and toxicodynamics to advance multi-organ toxicity testing (INTACT)

Version 1.1
Remco Westerink; Anne Kienhuis; Jelle Vriend; Jordi Minnema; Thijs Benschop; Bas Bokkers; Anne Zwartsen; Emma Kasteel; Agnes Oomen, 2026, "Integrated in vitro toxicokinetics and toxicodynamics to advance multi-organ toxicity testing (INTACT)", https://doi.org/10.21945/67D97F73-66DF-4357-B79F-8C0B376A583F, RIVM, V1
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Description
INTACT zal een getrapte aanpak hanteren om meerdere New Approach Methodologies (NAM's) modulair met elkaar te verbinden. Door de integratie van in vitro- en in silico-testen streven we ernaar om fysiologisch relevante blootstellingsroutes en de daaropvolgende distributie naar doelorganen na te bootsen, rekening houdend met barrières en metabolisme. Deze aanpak heeft als doel de vertaalbaarheid en voorspellende waarde van NAM's te vergroten voor hogere doorvoer van humane toxiciteitstesten.
Theme Science and technology
Keyword Chemische stoffen, geneesmiddelen, pesticiden
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